Lamina Lucida Roof

Dif on salt split skin reveals igg on the blister roof epidermal side of split skin in patients with bullous pemphigoid while in cp and.

Lamina lucida roof.

Bullous pemphigoid and subepidermal blistering dermatosis are autoimmune skin diseases characterized by the production of autoantibodies against basement membrane zone lamina lucida antigens that cause the epidermis to separate from the underlying dermis. It is a roughly 40 nanometre wide electron lucent zone between the plasma membrane of the basal cells and the electron dense lamina densa of the basement membrane. Of ethmoid bone the horizontal plate of ethmoid bone forming the roof of the nasal cavity and perforated by many foramina for passage of olfactory nerves. Of sclera the perforated part of the sclera through which pass the axons of the retinal ganglion cells.

Fragile vesicles and bullae form and rupture leaving ulcerated lesions. On account of these defective anchoring fibrils the subepidermal split occurs within or below the lamina densa leaving the lamina lucida attached to the roof of the epidermis. The lamina lucida is a component of the basement membrane which is found between the epithelium and underlying connective tissue e g epidermis and dermis of the skin.